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CD226 (DNAM-1) Rat anti-Mouse, Clone: 10E5, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

$216.05 - $549.55

Specifications

Antigen CD226 (DNAM-1)
Clone 1.00E+06
Host Species Rat
Gene Alias DNAM1, PTA1, Tlisa
Species Reactivity Mouse
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 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5014505

 
affymetrix
16-2261-81
50μg Each for $216.05

5014506

 
affymetrix
16226185
500μg Each for $549.55
Description & Specifications

Specifications

Antigen CD226 (DNAM-1)
Clone 1.00E+06
Host Species Rat
Gene Alias DNAM1, PTA1, Tlisa
Species Reactivity Mouse
Applications Flow Cytometry
Applications Functional Assay
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, no sodium azide
Concentration 1mg/mL

This 10E5 monoclonal antibody reacts with mouse CD226, which is also known as DNAX accessory molecule-1 (DNAM-1). CD226 is an adhesion molecule expressed primarily on T cells, including thymocytes. The highest levels of CD226 are found on naïve CD8 T cells. Moreover, expression of CD226 is regulated differentially in CD4 T cells. Under certain culture conditions, CD226 can be upregulated in Th1 and downregulated in Th2 and Th0 cells. This cell surface receptor can also be detected on natural killer cells, some B cell subsets, monocytes, and platelets. Interaction with its ligands, the poliovirus receptor (CD155) and CD112, results in adhesion and cell signaling events that promote innate and adaptive immunity, including differentiation, survival, and cytotoxicity.

The 10E5 monoclonal antibody has been reported to inhibit antigen-specific T cell proliferation and IFN-gamma production in vivo.