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CD223 (Lag-3) Rat anti-Mouse, PE-Cy7, Clone: eBioC9B7W (C9B7W), eBioscience™

Rat Monoclonal Antibody

$143.88 - $308.88

Specifications

Antigen CD223 (Lag-3)
Clone eBioC9B7W (C9B7W)
Host Species Rat
Applications Flow Cytometry
Regulatory Status RUO
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501123359 Life Technologies
LS25223180
25μg Each for $143.88
501129237 Life Technologies
LS25223182
100μg Each for $308.88
Specifications

Description

The eBioC9B7W monoclonal antibody recognizes mouse CD223 (LAG-3, LAG3) protein expressed by activated alpha/beta-TCR bearing T cells, a subset of gamma/delta-TCR bearing T cells and a subset of NK cells. CD223 is a 70kDa type I transmembrane protein with a structure that is similar to CD4. However, a soluble form of human CD223 has been detected by ELISA in human serum, and data suggest that mouse CD223 is proteolytically cleaved in the D4 domain. This results in a 54kDa fragment containing all the extracellular domains, and a 16kDa fragment containing the intracellular and transmembrane domains. The 54kDa can remain membrane-associated or be released as soluble CD223.

CD223 binds to MHC class II with higher affinity than CD4, and it is thought that this interaction is involved in the negative regulation of T-cell activation and homeostatic proliferation. Furthermore, CD223 is expressed by CD4+CD25+ regulatory T cells, and it has been suggested that CD223 may be involved in their regulatory function.
Description & Specifications

Specifications

CD223 (Lag-3)
Rat
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
eBioC9B7W (C9B7W)
Flow Cytometry
PE-Cy7
Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Monoclonal
0.2mg/mL