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CD221 (Insulin-like Growth Factor-1 Receptor) Mouse anti-Human, APC, Clone: 1H7, eBioscience™

Mouse Monoclonal Antibody

$172.55 - $375.55

Specifications

Antigen CD221 (Insulin-like Growth Factor-1 Receptor)
Clone 1H7
Host Species Mouse
Gene Alias IGF-1R
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5015332

 
affymetrix
17884941
25 tests Each for $172.55

5015333

 
affymetrix
17-8849-42
100 tests Each for $375.55
Description & Specifications

Specifications

Antigen CD221 (Insulin-like Growth Factor-1 Receptor)
Clone 1H7
Host Species Mouse
Gene Alias IGF-1R
Species Reactivity Human
Applications Flow Cytometry
Regulatory Status RUO
Conjugate APC
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.25μg)/test

This 1H7 monoclonal antibody reacts with human insulin-like growth factor-1 receptor (IGF-1R), also known as CD221. This receptor is a cell surface-expressed glycoprotein composed of two extracellular alpha subunits and two transmembrane beta subunits that possess tyrosine kinase activity. Expressed on nearly all cell types, this receptor binds IGF-I and IGF-II, as well as insulin. Ligand binding leads to activation of the PI3K/Akt and MAPK pathways, which mediate cell proliferation and survival. Many tumors and transformed cells display altered IGF-1R expression.

This monoclonal antibody has been reported to block binding of IGF-I and IGF-II to the IGF-1R.