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CD221 (Insulin-like Growth Factor-1 Receptor) Mouse anti-Human, Alexa Fluor 488, Clone: 1H7, eBioscience™

Mouse Monoclonal Antibody

$172.55 - $375.55

Specifications

Antigen CD221 (Insulin-like Growth Factor-1 Receptor)
Clone 1H7
Host Species Mouse
Gene Alias IGF1R
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

50246091

 
affymetrix
53884941
25 tests Each for $172.55

50246092

 
affymetrix
53884942
100 tests Each for $375.55
Description & Specifications

Specifications

Antigen CD221 (Insulin-like Growth Factor-1 Receptor)
Clone 1H7
Host Species Mouse
Gene Alias IGF1R
Species Reactivity Human
Applications Flow Cytometry
Regulatory Status RUO
Conjugate Alexa Fluor 488
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.5μg)/test

This 1H7 monoclonal antibody reacts with human insulin-like growth factor-1 receptor (IGF-1R), also known as CD221. This receptor is a cell surface-expressed glycoprotein composed of two extracellular alpha subunits and two transmembrane beta subunits that possess tyrosine kinase activity. Expressed on nearly all cell types, this receptor binds IGF-I and IGF-II, as well as insulin. Ligand binding leads to activation of the PI3K/Akt and MAPK pathways, which mediate cell proliferation and survival. Many tumors and transformed cells display altered IGF-1R expression.

This monoclonal antibody has been reported to block binding of IGF-I and IGF-II to the IGF-1R.