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CD22 Mouse anti-Human, APC, Clone: S-HCL-1, eBioscience™

Mouse Monoclonal Antibody

$143.88 - $341.88

Specifications

Antigen CD22
Clone S-HCL-1
Host Species Murine
Gene Alias siglec2, siglec 2
Species Reactivity Human
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
5015151 Life Technologies
LS17422941
25 Tests Each for $143.88
501128707 Life Technologies
LS17422942
100 Tests Each for $341.88
Specifications

Description

The S-HCl-1 monoclonal antibody recognizes human CD22 (Siglec-2), which is a member of the siglec subgroup of the Ig superfamily. CD22 is a type I transmembrane glycoprotein composed of two polypeptide chains, CD22a and CD22ß, of 130 and 140kDa respectively, produced by alternative splicing of the CD22 gene. CD22 is expressed at high levels on mature B cells and B cell lymphomas. The extracellular portion of CD22 contains seven Ig-like domains, some of which are capable of binding ligands with sialic acid moieties expressed on epithelial, endothelial, B and T cells. The intracellular portion of CD22 contains 6 tyrosine residues contained within immunotyrosine-based inhibitory motifs (ITIM) and immunotyrosine-based activation-like motifs, which are phosphorylated upon B-cell receptor engagement, which enables CD22 to participate in the positive and negative regulation of B-cell receptor signaling.
Description & Specifications

Specifications

CD22
Murine
Human
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, contains stabilizer if necessary
S-HCL-1
siglec2, siglec 2
Flow Cytometry
Allophycocyanin
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
5μL (0.125μg)/test