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CD22 Mouse anti-Human, APC, Clone: S-HCL-1, eBioscience™

Mouse Monoclonal Antibody

$158.05 - $375.55

Specifications

Antigen CD22
Clone S-HCL-1
Host Species Mouse
Gene Alias siglec2, siglec 2
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5015151

 
affymetrix
17-4229-41
25 tests Each for $158.05

501128707

 
affymetrix
17-4229-42
100 tests Each for $375.55
Description & Specifications

Specifications

Antigen CD22
Clone S-HCL-1
Host Species Mouse
Gene Alias siglec2, siglec 2
Species Reactivity Human
Applications Flow Cytometry
Regulatory Status RUO
Conjugate APC
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, contains stabilizer if necessary
Concentration 5μL (0.125μg)/test

The S-HCl-1 monoclonal antibody recognizes human CD22 (Siglec-2), which is a member of the siglec subgroup of the Ig superfamily. CD22 is a type I transmembrane glycoprotein composed of two polypeptide chains, CD22a and CD22ß, of 130 and 140kDa respectively, produced by alternative splicing of the CD22 gene. CD22 is expressed at high levels on mature B cells and B cell lymphomas. The extracellular portion of CD22 contains seven Ig-like domains, some of which are capable of binding ligands with sialic acid moieties expressed on epithelial, endothelial, B and T cells. The intracellular portion of CD22 contains 6 tyrosine residues contained within immunotyrosine-based inhibitory motifs (ITIM) and immunotyrosine-based activation-like motifs, which are phosphorylated upon B-cell receptor engagement, which enables CD22 to participate in the positive and negative regulation of B-cell receptor signaling.