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CD215 (IL-15 Receptor alpha) Mouse anti-Human, PE, Clone: eBioJM7A4, eBioscience™

Mouse Monoclonal Antibody

$216.05 - $433.55

Specifications

Antigen CD215 (IL-15 Receptor alpha)
Clone eBioJM7A4
Host Species Mouse
Gene Alias Interleukin-15 Receptor alpha, IL-15R, IL15R
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5011161

 
affymetrix
12-7159-41
25 tests Each for $216.05

501122381

 
affymetrix
12715942
100 tests Each for $433.55
Description & Specifications

Specifications

Antigen CD215 (IL-15 Receptor alpha)
Clone eBioJM7A4
Host Species Mouse
Gene Alias Interleukin-15 Receptor alpha, IL-15R, IL15R
Species Reactivity Human
Applications Flow Cytometry
Regulatory Status RUO
Conjugate PE
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.125μg)/test

The eBioJM7A4 monoclonal antibody reacts with the IL-15 receptor alpha chain (IL-15Rα). IL-15 and IL-2 are cytokines with overlapping, but distinct, biologic effects. Their receptors share 2 subunits, the IL-2Rβ and γ chains, which are essential for signal transduction. The IL-15Rα receptor is structurally related to IL-2Rα. However, the IL-15Rα alone binds IL-15 with a 1,000-fold higher affinity than that seen with IL-2Rα and IL-2. In the human, 3 differentially spliced human IL-15Rα variants that are all capable of high affinity binding of IL-15 have been isolated. The cytoplasmic domain of IL-15Rα, like that of IL-2Rα, is dispensable for mitogenic signaling, suggesting that the primary role of the alpha chains is to confer high affinity binding. At high concentrations, IL-15, like IL-2, is able to signal through a complex of IL-2Rβ and IL-2Rγ in the absence of the alpha subunit.