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CD21/CD35 Rat anti-Mouse, Biotin, Clone: eBio8D9 (8D9), eBioscience™

Rat Monoclonal Antibody

$129.05 - $230.55

Specifications

Antigen CD21/CD35
Clone eBio8D9 (8D9)
Host Species Rat
Gene Alias CR2/CR1, C3DR
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5011468

 
affymetrix
13-0211-81
50μg Each for $129.05

5011469

 
affymetrix
13021182
100μg Each for $230.55
Description & Specifications

Specifications

Antigen CD21/CD35
Clone eBio8D9 (8D9)
Host Species Rat
Gene Alias CR2/CR1, C3DR
Species Reactivity Mouse
Applications Flow Cytometry
Regulatory Status RUO
Conjugate Biotin
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The monoclonal antibody eBio8D9 reacts with an eptiope shared by mouse CD21 (CR2) and CD35 (CR1). CD21 and CD35 are alternatively spliced transcripts from the Cr2 gene, which produce cell-surface proteins of 145 and 190 kDa, respectively. CD21 and CD35 are expressed by mature B cells, but not on thymocytes, peripheral T cells, erythrocytes or platelets. Furthermore, there is some evidence which demonstrates their expression on macrophages. CD21 is a receptor for the complement component C3d and Epstein-Barr virus (EBV). In association with CD19 and CD81, CD21 also participates in B-cell activation through the B cell receptor. Cr2-deficient mice display impaired inflammatory and humoral immune responses in vivo.

The anti-mouse CD21/35 monoclonal antibody clones eBio4E3 and eBio8D9 do not cross-block each other, suggesting that they bind to different epitopes.