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CD209b (SIGN-R1) Armenian Hamster anti-Mouse, Clone: eBio22D1 (22D1), eBioscience™

Armenian Hamster Monoclonal Antibody

$114.55 - $187.05

Specifications

Antigen CD209b (SIGN-R1)
Clone eBio22D1 (22D1)
Host Species Armenian Hamster
Gene Alias C-type lectin, SIGNR1
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5012986

 
affymetrix
14209381
50μg Each for $114.55

5012987

 
affymetrix
14209382
100μg Each for $187.05
Description & Specifications

Specifications

Antigen CD209b (SIGN-R1)
Clone eBio22D1 (22D1)
Host Species Armenian Hamster
Gene Alias C-type lectin, SIGNR1
Species Reactivity Mouse
Applications Enzyme Linked Immunosorbent Assay
Applications Flow Cytometry
Applications Functional Assay
Applications Immunohistochemistry (Frozen)
Applications Immunoprecipitation
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The eBio22D1 monoclonal antibody reacts with mouse SIGNR1 (CD209b). SIGNR1 is a type II transmembrane C-type lectin that was identified in a search for mouse homologues of human DC-SIGN. It is expressed at high levels in splenic marginal zone macrophages and lymph node medullary macrophages, where it functions to uptake dextran polysaccharides, including the capsular polysaccharide of Streptococcus pneumoniae. It has also been demonstrated that SIGNR1 physically associates with TLR4/MD2, and it has been suggested that this association plays a role in recognition of LPS. Furthermore, recently it has been shown that SIGNR1 deficient mice have a defect in catabolism of the complement component C3, and that SIGNR1 binds directly to the complement C1 subcomponent, C1q to assemble a non-conventional C3 convertase. The eBio22D1 monoclonal antibody does not cross-react with the closely related SIGNR1, SIGNR2, SIGNR3 or SIGNR4.