Please login to your online account to display your discounted pricing

CD200 Receptor Rat anti-Mouse, PE, Clone: OX110, eBioscience™

Rat Monoclonal Antibody

$129.05 - $288.55

Specifications

Antigen CD200 Receptor
Clone OX110
Host Species Rat
Gene Alias CD200R, OX2R
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5010813

 
affymetrix
12-5201-80
25μg Each for $129.05

5010814

 
affymetrix
12520182
100μg Each for $288.55
Description & Specifications

Specifications

Antigen CD200 Receptor
Clone OX110
Host Species Rat
Gene Alias CD200R, OX2R
Species Reactivity Mouse
Applications Flow Cytometry
Regulatory Status RUO
Conjugate PE
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

The monoclonal antibody OX110 recognizes mouse CD200R also known as OX2. CD200R is an inhibitory receptor with a similar structure as its ligand, CD200, yet lacks an ITIM domain typically found in inhibitory receptors. Instead the CD200R cytoplasmic domain contains a novel phosphotyrosine binding domain NPXY, which after binding SHIP inhibits ERK, JNK and MAPK p38 pathways. In activated macrophages signaling results in inhibition of TNF alpha secretion.

Expression is restricted to hematopoietic cells: myeloid cells (monocytes, macrophages, DCs, neutrophils, mast cells and basophils) and a subset of lymphocytes as well as langerhans (LC) cells and dendritic epidermal T cells.