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CD200 Receptor Mouse anti-Human, Clone: OX108, Functional Grade, eBioscience™

Mouse Monoclonal Antibody, Functional Grade

$104.28 - $262.68

Specifications

Antigen CD200 Receptor
Clone OX108
Host Species Murine
Species Reactivity Human
Applications Flow Cytometry,Functional Assay
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
50245637 Life Technologies
LS16920182
100μg Each for $104.28
50245638 Life Technologies
LS16920185
500μg Each for $262.68
Specifications

Description

The monoclonal antibody OX108 recognizes human CD200R also known as OX2. CD200R is an inhibitory receptor with a similar structure as its ligand, CD200, yet lacks an ITIM domain typically found in inhibitory receptors. Instead the CD200R cytoplasmic domain contains a novel phosphotyrosine binding domain, NPXY, which after binding SHIP inhibits ERK, JNK and MAPK p38 pathways. In activated macrophages signaling results in inhibition of TNFα secretion. Isoforms of CD200R have been identified and are thought to play a major role in differentiation, especially in regards to tolerogenic DCs.

Expression is restricted to hematopoietic cells: myeloid cells (monocytes, macrophages, DCs, neutrophils, mast cells and basophils) and a subset of T lymphocytes as well as langerhans (LC) cells and dendritic epidermal T cells. The epitope of OX108 is thought to be near the binding site of CD200.
Description & Specifications

Specifications

CD200 Receptor
Murine
Flow Cytometry,Functional Assay
Unlabeled
Store at 2-8°C.
Monoclonal
1mg/mL
OX108
Human
RUO
Purified
Primary
aqueous buffer, no sodium azide