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CD20 Rat anti-Mouse, PE, Clone: QCH6A7, eBioscience™

Rat Monoclonal Antibody

$230.55 - $419.05

Specifications

Antigen CD20
Clone QCH6A7
Host Species Rat
Gene Alias Ms4a1, Ly-44
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501122215

 
affymetrix
12020380
25μg Each for $230.55

501122216

 
affymetrix
12020382
100μg Each for $419.05
Description & Specifications

Specifications

Antigen CD20
Clone QCH6A7
Host Species Rat
Gene Alias Ms4a1, Ly-44
Species Reactivity Mouse
Applications Flow Cytometry
Regulatory Status RUO
Conjugate PE
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

The monoclonal antibody QCH6A7 reacts with mouse CD20. CD20 is a B cell specific, 32kDa membrane protein that is expressed on late pro-B cells through memory B cells in the B cell lineage. CD20 is not found on hematopoietic stem cells, early pro-B cells or later mature plasma cells. CD20 is involved in intracellular calcium regulation and plays a role in B cell proliferation. CD20 is intially expressed after the induction of CD19 during development and is coexpressed with IgM during the pre-B to immature B cell transition in bone marrow. Expression of CD20 increases during maturation with almost all mature B cells expressing some level of CD20. Unlike other B cell antigens, CD20 is not shed or internalized upon antibody binding. Monoclonal antibodies against the CD20 antigen may be used to deplete B cells and CD20 has proven to be an effective immunotheraputic target in B cell lymphomas and several autoimmune diseases including rheumatoid arthritis and type I diabetes. CD20 consists of 4 transmembrane domains and a 44 amino acid extracellular domain which contains the QCH6A7 epitope.

Staining with clone QCH6A7 provides significantly improved staining intensity compared to clone AISB12 in flow cytometric assays.