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CD20 Mouse anti-Human, Clone: L26, eBioscience™

Mouse Monoclonal Antibody

$114.55 - $288.55

Specifications

Antigen CD20
Clone L26
Host Species Mouse
Gene Alias B1, MS4A2, Leu-16
Species Reactivity Cynomolgus, Human, Rhesus Ma
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 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

50245548

 
affymetrix
14020280
25μg Each for $114.55

50245549

 
affymetrix
14020282
100μg Each for $288.55
Description & Specifications

Specifications

Antigen CD20
Clone L26
Host Species Mouse
Gene Alias B1, MS4A2, Leu-16
Species Reactivity Cynomolgus, Human, Rhesus Ma
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Immunohistochemistry (Frozen)
Applications Immunoprecipitation
Applications Western Blotting
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The monoclonal antibody L26 recognizes human CD20, a two transmembrane spanning protein found on precursor and mature B lymphocytes. Expression is lost upon differentiation to plasma cells. The levels of CD20 are critical in evaluating malignant B lymphocytes including Non-Hodgkin’s Lymphoma, and Acute B cell, Chronic Lymphocytic and Hairy-Cell Leukemias. CD20 plays a role in B cell differentiation and activation. The structure of the protein shows a small extracellular loop with the carboxy and amino termini in the cytoplasmic compartment. The L26 antibody recognizes an epitope in the cytoplasmic domain and therefore requires permeabilization of the tissue for staining applications. Unlike many anti-CD20 antibodies that recognize the extracellular domain, the epitope recognized by L26 will not be blocked by therapeutic antibodies to CD20, like Rituximab.