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CD197 (CCR7) Rat anti-Human, Biotin, Clone: 3D12, eBioscience™

Rat Monoclonal Antibody

$117.48 - $289.08

Specifications

Antigen CD197 (CCR7)
Clone 3D12
Host Species Rat
Gene Alias EBI-1, MIP-3 beta Receptor
Species Reactivity Human
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
5011810 Life Technologies
LS13197980
25μg Each for $117.48
5011811 Life Technologies
LS13197982
100μg Each for $289.08
Specifications

Description

The 3D12 monoclonal antibody reacts with human CCR7, also known as EBI-1 and CD197. CCR7 is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains and functions as a receptor for 6Ckine/SLC (secondary lymphoid-tissue chemokine), CCL19 and CCL21. CCR7 has been shown to be internalized via clathrin-coated pits and the majority recycled back to the plasma membrane. CCR7 is expressed on T cells and can be used to distinguish populations of naïve from central and effector memory T cells. CCR7 has been shown to play a role in migration of memory T cells to inflamed tissue. Expression of CCR7 is also found on DC’s. During DC maturation CCR7 expression increases and is thought to be involved in a variety of functions: chemotaxis to the lymph node, cellular architecture, rate of endocytosis, survival and maturation. Expression of CCR7 on the cell surface can be down regulated upon ligand binding.
Description & Specifications

Specifications

CD197 (CCR7)
Rat
Human
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
3D12
EBI-1, MIP-3 beta Receptor
Flow Cytometry
Biotin
Store at 2-8°C. Do not freeze.
Monoclonal
0.5mg/mL