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CD197 (CCR7) Rat anti-Human, APC-eFluor 780, Clone: 3D12, eBioscience™

Rat Monoclonal Antibody

$200.64 - $469.92

Specifications

Antigen CD197 (CCR7)
Clone 3D12
Host Species Rat
Gene Alias EBI-1, MIP-3 beta Receptor
Species Reactivity Human
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
5016193 Life Technologies
LS47197941
25 Tests Each for $200.64
501129419 Life Technologies
LS47197942
100 Tests Each for $469.92
Specifications

Description

The 3D12 monoclonal antibody reacts with human CCR7, also known as EBI-1 and CD197. CCR7 is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains and functions as a receptor for 6Ckine/SLC (secondary lymphoid-tissue chemokine), CCL19 and CCL21. CCR7 has been shown to be internalized via clathrin-coated pits and the majority recycled back to the plasma membrane. CCR7 is expressed on T cells and can be used to distinguish populations of naïve from central and effector memory T cells. CCR7 has been shown to play a role in migration of memory T cells to inflamed tissue. Expression of CCR7 is also found on DC’s. During DC maturation CCR7 expression increases and is thought to be involved in a variety of functions: chemotaxis to the lymph node, cellular architecture, rate of endocytosis, survival and maturation. Expression of CCR7 on the cell surface can be down regulated upon ligand binding.
Description & Specifications

Specifications

CD197 (CCR7)
Rat
Human
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
3D12
EBI-1, MIP-3 beta Receptor
Flow Cytometry
APC-eFluor 780
Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Monoclonal
5μL (1μg)/test