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CD185 (CXCR5) Mouse anti-Non-human primate, PE, Clone: 87.1, eBioscience™

Mouse Monoclonal Antibody

$187.05 - $477.05

Specifications

Antigen CD185 (CXCR5)
Clone 87.1
Host Species Mouse
Gene Alias C-X-C chemokine receptor type 5, BLR1, MDR15
Species Reactivity Non-human primate
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501122287

 
affymetrix
12185941
25 tests Each for $187.05

501122288

 
affymetrix
12185942
100 tests Each for $477.05

501128933

 
affymetrix
12-2075-82
100μg Each for $448.05

501129522

 
affymetrix
12-9985-82
100μg Each for $317.55
Description & Specifications

Specifications

Antigen CD185 (CXCR5)
Clone 87.1
Host Species Mouse
Gene Alias C-X-C chemokine receptor type 5, BLR1, MDR15
Species Reactivity Non-human primate
Applications Flow Cytometry
Regulatory Status RUO
Conjugate PE
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.125μg)/test

This 87.1 monoclonal antibody reacts with non-human primate (specifically rhesus) CD185. CD185, which is also known as C-X-C chemokine receptor 5 (CXCR5) and Burkitt lymphoma receptor 1 (BLR1), is a seven transmembrane G protein-coupled receptor originally identified in Burkitt’s lymphoma. In peripheral blood, CD185 is expressed on B cells, CD4+ T cells (but not Th1 or Th2 cells), and a subpopulation of memory (CD45RO+) T cells. CD185+ circulating T cells are in a resting state and migrate to the lymph nodes due to CCR7 and CD62L expression. In tonsils, CD185 is expressed on nearly all CD4+ cells along with CD45RO and the activation markers CD69 and ICOS. Tonsillar CD185+ cells have been shown to induce antibody production when co-cultured with B cells, thus supporting their role in providing B cell help. Furthermore, this chemokine receptor plays a critical role in lymphocyte trafficking, in particular CXCL13-induced T cell migration into the B cell follicles of germinal centers. Thus, CD185 is an established marker of follicular helper T cells (Tfh). In rhesus macaques, infection with simian immunodeficiency virus (SIV) has been reported to increase the number of germinal centers and Tfh cells within the lymph nodes.

Refer to the rhesus reactive alternative clone MU5UBEE (cat. 12-9185) for identification of CXCR5 on T cells in addition to B cells.