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CD185 (CXCR5) Mouse anti-Non-human primate, PE, Clone: 87.1, eBioscience™

Mouse Monoclonal Antibody

$170.28 - $434.28

Specifications

Antigen CD185 (CXCR5)
Clone 87.1
Host Species Murine
Gene Alias C-X-C chemokine receptor type 5, BLR1, MDR15
Applications Flow Cytometry
View More Specs

Disclaimers:

For Research Use Only.



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Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501122287 Life Technologies
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501122288 Life Technologies
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100 Tests Each for $434.28
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Specifications

Description

This 87.1 monoclonal antibody reacts with non-human primate (specifically rhesus) CD185. CD185, which is also known as C-X-C chemokine receptor 5 (CXCR5) and Burkitt lymphoma receptor 1 (BLR1), is a seven transmembrane G protein-coupled receptor originally identified in Burkitt’s lymphoma. In peripheral blood, CD185 is expressed on B cells, CD4+ T cells (but not Th1 or Th2 cells), and a subpopulation of memory (CD45RO+) T cells. CD185+ circulating T cells are in a resting state and migrate to the lymph nodes due to CCR7 and CD62L expression. In tonsils, CD185 is expressed on nearly all CD4+ cells along with CD45RO and the activation markers CD69 and ICOS. Tonsillar CD185+ cells have been shown to induce antibody production when co-cultured with B cells, thus supporting their role in providing B cell help. Furthermore, this chemokine receptor plays a critical role in lymphocyte trafficking, in particular CXCL13-induced T cell migration into the B cell follicles of germinal centers. Thus, CD185 is an established marker of follicular helper T cells (Tfh). In rhesus macaques, infection with simian immunodeficiency virus (SIV) has been reported to increase the number of germinal centers and Tfh cells within the lymph nodes.

Refer to the rhesus reactive alternative clone MU5UBEE (cat. 12-9185) for identification of CXCR5 on T cells in addition to B cells.
Description & Specifications

Specifications

CD185 (CXCR5)
Murine
Flow Cytometry
PE
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
5μL (0.125μg)/test
87.1
C-X-C chemokine receptor type 5, BLR1, MDR15
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer