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CD185 (CXCR5) Mouse anti-Non-human primate, PE, Clone: 87.1, eBioscience™

Mouse Monoclonal Antibody

$170.28 - $434.28

Specifications

Antigen CD207 (Langerin)
Clone eBioL31
Host Species Rat
Gene Alias Clec4K
Species Reactivity Mouse
View More Specs

Disclaimers:

For Research Use Only.



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Specifications

Description

This 87.1 monoclonal antibody reacts with non-human primate (specifically rhesus) CD185. CD185, which is also known as C-X-C chemokine receptor 5 (CXCR5) and Burkitt lymphoma receptor 1 (BLR1), is a seven transmembrane G protein-coupled receptor originally identified in Burkitt’s lymphoma. In peripheral blood, CD185 is expressed on B cells, CD4+ T cells (but not Th1 or Th2 cells), and a subpopulation of memory (CD45RO+) T cells. CD185+ circulating T cells are in a resting state and migrate to the lymph nodes due to CCR7 and CD62L expression. In tonsils, CD185 is expressed on nearly all CD4+ cells along with CD45RO and the activation markers CD69 and ICOS. Tonsillar CD185+ cells have been shown to induce antibody production when co-cultured with B cells, thus supporting their role in providing B cell help. Furthermore, this chemokine receptor plays a critical role in lymphocyte trafficking, in particular CXCL13-induced T cell migration into the B cell follicles of germinal centers. Thus, CD185 is an established marker of follicular helper T cells (Tfh). In rhesus macaques, infection with simian immunodeficiency virus (SIV) has been reported to increase the number of germinal centers and Tfh cells within the lymph nodes.

Refer to the rhesus reactive alternative clone MU5UBEE (cat. 12-9185) for identification of CXCR5 on T cells in addition to B cells.
Description & Specifications

Specifications

CD207 (Langerin)
Rat
Mouse
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
eBioL31
Clec4K
Flow Cytometry (Intracellular Staining)
PE
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
0.2mg/mL