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CD184 (CXCR4) Rat anti-Mouse, eFluor 450, Clone: 2B11, eBioscience™

Rat Monoclonal Antibody

$187.05 - $433.55

Specifications

Antigen CD184 (CXCR4)
Clone 2B11
Host Species Rat
Gene Alias Fusin, C-X-C chemokine receptor type 4, SDF-1 Receptor
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501124239

 
affymetrix
48999180
25μg Each for $187.05

501124240

 
affymetrix
48999182
100μg Each for $433.55
Description & Specifications

Specifications

Antigen CD184 (CXCR4)
Clone 2B11
Host Species Rat
Gene Alias Fusin, C-X-C chemokine receptor type 4, SDF-1 Receptor
Species Reactivity Mouse
Applications Flow Cytometry
Regulatory Status RUO
Conjugate eFluor 450
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

The 2B11 monoclonal antibody reacts with mouse and human CXCR4, also known as CD184, Fusin, LESTR, or HUMSTR. Fusin is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains, and functions as a coreceptor for X4 HIV-1 entry into CD4+ cells. In addition it has been shown to play a role in lymphocyte migration. The ligand for CXCR4 is SDF1. CXCR4 is required for maintenance of granulocyte progenitors in the bone marrow and essential for B cell development. Expression of CXCR4 is different between mice and human. In the thymus CXCR4 is restricted to CD4+CD8+ cells while in the spleen predominant expression is found on B lymphocytes.

The monoclonal antibody 2B11 recognizes the amino terminus of CXCR4 and has been reported to have functional activity; it does not block SDF1a but causes internalization of the receptor.