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CD184 (CXCR4) Rat anti-Mouse, Biotin, Clone: 2B11, eBioscience™

Rat Monoclonal Antibody

$129.05 - $317.55

Specifications

Antigen CD184 (CXCR4)
Clone 2B11
Host Species Rat
Gene Alias Fusin
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5012313

 
affymetrix
13999180
25μg Each for $129.05

5012314

 
affymetrix
13-9991-82
100μg Each for $317.55
Description & Specifications

Specifications

Antigen CD184 (CXCR4)
Clone 2B11
Host Species Rat
Gene Alias Fusin
Species Reactivity Mouse
Applications Flow Cytometry
Regulatory Status RUO
Conjugate Biotin
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The 2B11 monoclonal antibody reacts with mouse and human CXCR4, also known as CD184, Fusin, LESTR, or HUMSTR. Fusin is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains, and functions as a coreceptor for X4 HIV-1 entry into CD4+ cells. In addition it has been shown to play a role in lymphocyte migration. The ligand for CXCR4 is SDF1. CXCR4 is required for maintenance of granulocyte progenitors in the bone marrow and essential for B cell development. Expression of CXCR4 is different between mice and human. In the thymus CXCR4 is restricted to CD4+CD8+ cells while in the spleen predominant expression is found on B lymphocytes.

The monoclonal antibody 2B11 recognizes the amino terminus of CXCR4 and has been reported to have functional activity; it does not block SDF1a but causes internalization of the receptor.