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CD184 (CXCR4) Mouse anti-Human, PE-Cy5, Clone: 12G5, eBioscience™

Mouse Monoclonal Antibody

$201.55 - $419.05

Specifications

Antigen CD184 (CXCR4)
Clone 12G5
Host Species Mouse
Gene Alias Fusin
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5014166

 
affymetrix
15-9999-41
25 tests Each for $201.55

5014167

 
affymetrix
15-9999-42
100 tests Each for $419.05
Description & Specifications

Specifications

Antigen CD184 (CXCR4)
Clone 12G5
Host Species Mouse
Gene Alias Fusin
Species Reactivity Human
Applications Flow Cytometry
Regulatory Status RUO
Conjugate PE-Cy5
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.5μg)/test

The 12G5 monoclonal antibody reacts with human CD184 (CXCR4), also termed Fusin, LESTR, or HUMSTR. CD184 is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains, and functions as a coreceptor for X4 HIV-1 entry into CD4+ cells. CD184 is expressed predominantly on naïve T cell subsets of peripheral blood and is rapidly upregulated by PHA and IL-2 stimulation. The 12G5 antibody shows partial inhibition of chemotaxis and calcium influx induced by SDF-1 (the natural ligand of CD184), blocks CD4-independent HIV-2 infection, and blocks CD4-dependent infection by some T-tropic HIV-1 isolates.