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CD183 (CXCR3) Armenian Hamster anti-Mouse, PE-Cy7, Clone: CXCR3-173, eBioscience™

Armenian Hamster Monoclonal Antibody

$201.55 - $491.55

Specifications

Antigen CD183 (CXCR3)
Clone CXCR3-173
Host Species Armenian Hamster
Gene Alias C-X-C chemokine receptor type 3, IP-10 receptor
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501123347

 
affymetrix
25183180
25μg Each for $201.55

501123348

 
affymetrix
25183182
100μg Each for $491.55
Description & Specifications

Specifications

Antigen CD183 (CXCR3)
Clone CXCR3-173
Host Species Armenian Hamster
Gene Alias C-X-C chemokine receptor type 3, IP-10 receptor
Species Reactivity Mouse
Applications Flow Cytometry
Regulatory Status RUO
Conjugate PE-Cy7
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

The monoclonal antibody CXCR3-173 recognizes mouse CD183 also known as CXCR3. CD183 is a seven transmembrane G-protein liked chemokine receptor which binds three ligands; CXCL9 (mig), CXCL10 (IP-10)and CXCL11 (ITAC). CD183 as been shown to play a role in CD4 T cell responses to grafts. CXCR3 knockout mice have compromised allograft rejection responses. Expression is found on NK cells, a subset of T lymphocytes and a subset of Tregs as well as preferential expression on Th1-polarized cells.

The antibody CXCR3-173 has been shown to affect chemotaxis in response to ligand. The presence of ligand eliminates staining with the antibody. In vivo addition of the antibody delays cardiac and pancreatic islet allograft rejection.