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CD183 (CXCR3) Armenian Hamster anti-Mouse, Clone: CXCR3-173, Functional Grade, eBioscience™

Armenian Hamster Monoclonal Antibody, Functional Grade

$245.05 - $477.05

Specifications

Antigen CD183 (CXCR3)
Clone CXCR3-173
Host Species Armenian Hamster
Gene Alias C-X-C chemokine receptor type 3, IP-10 receptor
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5014494

 
affymetrix
16-1831-85
500μg Each for $477.05

5014493

 
affymetrix
16-1831-81
50μg Each for $245.05
Description & Specifications

Specifications

Antigen CD183 (CXCR3)
Clone CXCR3-173
Host Species Armenian Hamster
Gene Alias C-X-C chemokine receptor type 3, IP-10 receptor
Species Reactivity Mouse
Applications Flow Cytometry
Applications Functional Assay
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, no sodium azide
Concentration 1mg/mL

The monoclonal antibody CXCR3-173 recognizes mouse CD183 also known as CXCR3. CD183 is a seven transmembrane G-protein liked chemokine receptor which binds three ligands; CXCL9 (mig), CXCL10 (IP-10)and CXCL11 (ITAC). CD183 as been shown to play a role in CD4 T cell responses to grafts. CXCR3 knockout mice have compromised allograft rejection responses. Expression is found on NK cells, a subset of T lymphocytes and a subset of Tregs as well as preferential expression on Th1-polarized cells.

The antibody CXCR3-173 has been shown to affect chemotaxis in response to ligand. The presence of ligand eliminates staining with the antibody. In vivo addition of the antibody delays cardiac and pancreatic islet allograft rejection.