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CD182 (CXCR2) Mouse anti-Human, PerCP-eFluor 710, Clone: ebio5E8-C7-F10 (5E8-C7-F10), eBioscience™

Mouse Monoclonal Antibody

$157.08 - $368.28

Specifications

Antigen CD182 (CXCR2)
Clone ebio5E8-C7-F10 (5E8-C7-F10)
Host Species Murine
Gene Alias C-X-C chemokine receptor type 2, Interleukin-8 Receptor B
Applications Flow Cytometry
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501123786 Life Technologies
LS46182942
100 Tests Each for $368.28
501130789 Life Technologies
LS46182941
25 Tests Each for $157.08
Specifications

Description

The eBio5E8-C7-F10 monoclonal antibody reacts with human CD182 (CXCR2, IL-8R beta). CD182 is a 67-70kDa member of the seven-transmembrane spanning G-protein coupled receptor (GPCR) family. CD182 is expressed as a homodimer, or a heterodimer with CD181 (CXCR1, IL-8R alpha) and is expressed on granulocytes, NK cells, a subset of T cells, mast cells, monocytes, endothelial cells, megakaryocytes and oligodendrocytes. Binding of it's ligands, which include IL-8, NAP-2, GCP-2 and GRO alpha, -beta and -gamma, induces several biological outcomes such as cell activation, chemotaxis, proliferation and angiogenesis. There are several functional differences between CD181 and CD182. Both receptors are able to mediate chemotaxis and intracellular calcium changes, but only CD181 mediates phospolipase D activation and respiratory burst. Furthermore, studies have shown that IL-8 predominantly mediates its effects on neutrophil function through CD181.
Description & Specifications

Specifications

CD182 (CXCR2)
Murine
Flow Cytometry
PerCP-eFluor 710
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
5μL (0.25μg)/test
ebio5E8-C7-F10 (5E8-C7-F10)
C-X-C chemokine receptor type 2, Interleukin-8 Receptor B
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer