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CD181 (CXCR1) Mouse anti-Human, FITC, Clone: eBio8F1-1-4 (8F1-1-4), eBioscience™

Mouse Monoclonal Antibody

$130.68 - $289.08

Specifications

Antigen CD181 (CXCR1)
Clone eBio8F1-1-4 (8F1-1-4)
Host Species Murine
Gene Alias Interleukin-8 Receptor A, IL-8Ra, IL8RA
Applications Flow Cytometry
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501122103 Life Technologies
LS11181941
25 Tests Each for $130.68
501122104 Life Technologies
LS11181942
100 Tests Each for $289.08
Specifications

Description

The eBio8F1-1-4 monoclonal antibody reacts with human CD181 (CXCR1, IL-8Rα). CD181 is a 67-70kDa member of the 7-transmembrane spanning G-protein coupled receptor (GPCR) family. CD181 is expressed as a homodimer, or a heterodimer with CD182 (CXCR2, IL-8Rβ) and is expressed on granulocytes, NK cells, a subset of T cells, mast cells, monocytes, endothelial cells, megakaryocytes and oligodendrocytes. Binding of it's ligands, which include IL-8, NAP-2, GCP-2 and GRO-α, induces several biological outcomes such as cell activation, chemotaxis, proliferation and angiogenesis. There are several functional differences between CD181 and CD182. Both receptors are able to mediate chemotaxis and intracellular calcium changes, but only CD181 mediates phospolipase D activation and respiratory burst. Furthermore, studies have shown that IL-8 predominantly mediates its effects on neutrophil function through CD181.
Description & Specifications

Specifications

CD181 (CXCR1)
Murine
Flow Cytometry
FITC
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
5μL (0.5μg)/test
eBio8F1-1-4 (8F1-1-4)
Interleukin-8 Receptor A, IL-8Ra, IL8RA
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer