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CD181 (CXCR1) Mouse anti-Human, Clone: eBio8F1-1-4 (8F1-1-4), eBioscience™

Mouse Monoclonal Antibody

$85.55 - $158.05

Specifications

Antigen CD181 (CXCR1)
Clone eBio8F1-1-4 (8F1-1-4)
Host Species Mouse
Gene Alias Interleukin-8 Receptor A, IL-8Ra, IL8RA
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5012948

 
affymetrix
14-1819-80
25μg Each for $85.55

5012949

 
affymetrix
14-1819-82
100μg Each for $158.05
Description & Specifications

Specifications

Antigen CD181 (CXCR1)
Clone eBio8F1-1-4 (8F1-1-4)
Host Species Mouse
Gene Alias Interleukin-8 Receptor A, IL-8Ra, IL8RA
Species Reactivity Human
Applications Flow Cytometry
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The eBio8F1-1-4 monoclonal antibody reacts with human CD181 (CXCR1, IL-8Rα). CD181 is a 67-70kDa member of the 7-transmembrane spanning G-protein coupled receptor (GPCR) family. CD181 is expressed as a homodimer, or a heterodimer with CD182 (CXCR2, IL-8Rβ) and is expressed on granulocytes, NK cells, a subset of T cells, mast cells, monocytes, endothelial cells, megakaryocytes and oligodendrocytes. Binding of it's ligands, which include IL-8, NAP-2, GCP-2 and GRO-α, induces several biological outcomes such as cell activation, chemotaxis, proliferation and angiogenesis. There are several functional differences between CD181 and CD182. Both receptors are able to mediate chemotaxis and intracellular calcium changes, but only CD181 mediates phospolipase D activation and respiratory burst. Furthermore, studies have shown that IL-8 predominantly mediates its effects on neutrophil function through CD181.