Please login to your online account to display your discounted pricing

CD180 (RP105) Mouse anti-Human, PE, Clone: MHR73-11, eBioscience™

Mouse Monoclonal Antibody

$172.55 - $361.05

Specifications

Antigen CD180 (RP105)
Clone MHR73-11
Host Species Murine
Gene Alias RP-105, Toll-like Receptor, TLR Family
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5010687

 
life technologies
LS12180941
25 Tests Each for $172.55

5010688

 
life technologies
LS12180942
100 Tests Each for $361.05
Description & Specifications

Specifications

Antigen CD180 (RP105)
Clone MHR73-11
Host Species Murine
Gene Alias RP-105, Toll-like Receptor, TLR Family
Species Reactivity Human
Applications Flow Cytometry
Regulatory Status RUO
Conjugate PE
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.5μg)/test

The MHR73-11 monoclonal antibody reacts with human CD180 (RP105). This 105kDa type I transmembrane molecule is a member of the TLR family of proteins characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. RP105 physically associates with another molecule called MD-1 and is expressed on B, monocytes/macrophages, and dendritic cells. Histological studies show that RP105 is expressed mainly on mature B cells in mantle zones, while germinal center cells are either dull or negative. The RP105/MD-1 complex in concert with TLR4 mediates B cell recognition and signaling of LPS. MHR73-11 activates B cells, leading to increases in cell size, expression of the costimulatory molecule CD80, and DNA synthesis. Moreover, ligation of RP105 protects B cells from irradiation- or dexamethasone-induced apoptosis. Thus, RP105 is a signal transduction molecule and plays a role in regulation of B cell growth and death. A significant proportion of circulating B cells in SLE patients is RP105 negative. Loss of RP105 is associated with B cell activation and increased disease activity in SLE patients.