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CD180 (RP105) Mouse anti-Human, Clone: MHR73-11, eBioscience™

Mouse Monoclonal Antibody

$129.05 - $259.55

Specifications

Antigen CD180 (RP105)
Clone MHR73-11
Host Species Murine
Gene Alias RP-105, Toll-like Receptor, TLR Family
Species Reactivity Human
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
5012946 Life Technologies
LS14180980
25μg Each for $129.05
5012947 Life Technologies
LS14180982
100μg Each for $259.55
Specifications

Description

The MHR73-11 monoclonal antibody reacts with human CD180 (RP105). This 105kDa type I transmembrane molecule is a member of the TLR family of proteins characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. RP105 physically associates with another molecule called MD-1 and is expressed on B, monocytes/macrophages, and dendritic cells. Histological studies show that RP105 is expressed mainly on mature B cells in mantle zones, while germinal center cells are either dull or negative. The RP105/MD-1 complex in concert with TLR4 mediates B cell recognition and signaling of LPS. MHR73-11 activates B cells, leading to increases in cell size, expression of the costimulatory molecule CD80, and DNA synthesis. Moreover, ligation of RP105 protects B cells from irradiation- or dexamethasone-induced apoptosis. Thus, RP105 is a signal transduction molecule and plays a role in regulation of B cell growth and death. A significant proportion of circulating B cells in SLE patients is RP105 negative. Loss of RP105 is associated with B cell activation and increased disease activity in SLE patients.
Description & Specifications

Specifications

CD180 (RP105)
Murine
Human
RUO
Purified
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
MHR73-11
RP-105, Toll-like Receptor, TLR Family
Flow Cytometry,Functional Assay,Immunohistochemistry,Immunoprecipitation
Unlabeled
Store at 2-8°C.
Monoclonal
0.5mg/mL