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CD172a (SIRP alpha) Rat anti-Mouse, PE, Clone: P84, eBioscience™

Rat Monoclonal Antibody

$201.55 - $462.55

Specifications

Antigen CD172a (SIRP alpha)
Clone P84
Host Species Rat
Gene Alias SHPS-1, Signal-regulatory protein alpha-1
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501122282

 
affymetrix
12172180
25μg Each for $201.55

501122283

 
affymetrix
12172182
100μg Each for $462.55
Description & Specifications

Specifications

Antigen CD172a (SIRP alpha)
Clone P84
Host Species Rat
Gene Alias SHPS-1, Signal-regulatory protein alpha-1
Species Reactivity Mouse
Applications Flow Cytometry
Regulatory Status RUO
Conjugate PE
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

This P84 monoclonal antibody reacts with mouse CD172a, also known as signal regulatory protein a (SIRPa). This cell surface glycoprotein consists of three Ig-like extracellular domains and two cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The ITIM domains have been demonstrated to recruit and bind the Src homology 2 domain-containing phosphatases SHP-1 and SHP-2. CD172a is expressed on monocytes, macrophages, dendritic cells, but not on T and B lymphocytes. Moreover, neurons and other tissues of the central nervous system have also been shown to express CD172a. The integrin-associated protein CD47 is the extracellular ligand for CD172a. Studies show that CD172a is involved in dendritic cell-mediated T cell activation, neutrophil migration, and phagocytosis.

This monoclonal antibody has been reported to have neutralizing activity.