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This monoclonal antibody has been reported to have neutralizing activity.Description & Specifications
DescriptionThis P84 monoclonal antibody reacts with mouse CD172a, also known as signal regulatory protein a (SIRPa). This cell surface glycoprotein consists of three Ig-like extracellular domains and two cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The ITIM domains have been demonstrated to recruit and bind the Src homology 2 domain-containing phosphatases SHP-1 and SHP-2. CD172a is expressed on monocytes, macrophages, dendritic cells, but not on T and B lymphocytes. Moreover, neurons and other tissues of the central nervous system have also been shown to express CD172a. The integrin-associated protein CD47 is the extracellular ligand for CD172a. Studies show that CD172a is involved in dendritic cell-mediated T cell activation, neutrophil migration, and phagocytosis.
This monoclonal antibody has been reported to have neutralizing activity.
|CD172a (SIRP alpha)|
|Store at 2-8°C. Do not freeze. Light-sensitive material.|
|SHPS-1, Signal-regulatory protein alpha-1|
|aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer|