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CD172a (SIRP alpha) Rat anti-Mouse, PE, Clone: P84, eBioscience™

Rat Monoclonal Antibody

$183.48 - $421.08

Specifications

Antigen CD172a (SIRP alpha)
Clone P84
Host Species Rat
Gene Alias SHPS-1, Signal-regulatory protein alpha-1
Applications Flow Cytometry
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501122282 Life Technologies
LS12172180
25μg Each for $183.48
501122283 Life Technologies
LS12172182
100μg Each for $421.08
Specifications

Description

This P84 monoclonal antibody reacts with mouse CD172a, also known as signal regulatory protein a (SIRPa). This cell surface glycoprotein consists of three Ig-like extracellular domains and two cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The ITIM domains have been demonstrated to recruit and bind the Src homology 2 domain-containing phosphatases SHP-1 and SHP-2. CD172a is expressed on monocytes, macrophages, dendritic cells, but not on T and B lymphocytes. Moreover, neurons and other tissues of the central nervous system have also been shown to express CD172a. The integrin-associated protein CD47 is the extracellular ligand for CD172a. Studies show that CD172a is involved in dendritic cell-mediated T cell activation, neutrophil migration, and phagocytosis.

This monoclonal antibody has been reported to have neutralizing activity.
Description & Specifications

Specifications

CD172a (SIRP alpha)
Rat
Flow Cytometry
PE
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
0.2mg/mL
P84
SHPS-1, Signal-regulatory protein alpha-1
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer