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CD172a (SIRP alpha) Rat anti-Mouse, Clone: P84, Functional Grade, eBioscience™

Rat Monoclonal Antibody, Functional Grade

$196.68 - $460.68

Specifications

Antigen CD172a (SIRP alpha)
Clone P84
Host Species Rat
Gene Alias SHPS-1, Signal-regulatory protein alpha-1
Species Reactivity Mouse
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
50245622 Life Technologies
LS16172181
50μg Each for $196.68
50245623 Life Technologies
LS16172185
500μg Each for $460.68
Specifications

Description

This P84 monoclonal antibody reacts with mouse CD172a, also known as signal regulatory protein a (SIRPa). This cell surface glycoprotein consists of three Ig-like extracellular domains and two cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The ITIM domains have been demonstrated to recruit and bind the Src homology 2 domain-containing phosphatases SHP-1 and SHP-2. CD172a is expressed on monocytes, macrophages, dendritic cells, but not on T and B lymphocytes. Moreover, neurons and other tissues of the central nervous system have also been shown to express CD172a. The integrin-associated protein CD47 is the extracellular ligand for CD172a. Studies show that CD172a is involved in dendritic cell-mediated T cell activation, neutrophil migration, and phagocytosis.

This monoclonal antibody has been reported to have neutralizing activity.
Description & Specifications

Specifications

CD172a (SIRP alpha)
Rat
Mouse
RUO
Purified
Primary
aqueous buffer, no sodium azide
P84
SHPS-1, Signal-regulatory protein alpha-1
Flow Cytometry,Functional Assay
Unlabeled
Store at 2-8°C.
Monoclonal
1mg/mL