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CD172a (SIRP alpha) Mouse anti-Human, APC, Clone: 15-414, eBioscience™

Mouse Monoclonal Antibody

$172.55 - $375.55

Specifications

Antigen CD172a (SIRP alpha)
Clone 15-414
Host Species Mouse
Gene Alias SIRPa, SHPS-1
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5015109

 
affymetrix
17-1729-41
25 tests Each for $172.55

5015110

 
affymetrix
17-1729-42
100 tests Each for $375.55
Description & Specifications

Specifications

Antigen CD172a (SIRP alpha)
Clone 15-414
Host Species Mouse
Gene Alias SIRPa, SHPS-1
Species Reactivity Human
Applications Flow Cytometry
Regulatory Status RUO
Conjugate APC
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.5μg)/test

This 15-414 monoclonal antibody reacts with human CD172a, also known as signal regulatory protein alpha (SIRP alpha). This cell surface glycoprotein consists of three Ig-like extracellular domains and two cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The ITIM domains have been demonstrated to recruit and bind the Src homology 2 domain-containing phosphatases SHP-1 and SHP-2. CD172a is expressed on monocytes, granulocytes, dendritic cells, and CD34+CD38- hematopoietic progenitor cells but not on T and B lymphocytes. Moreover, neurons have also been shown to express CD172. The integrin-associated protein CD47 is the extracellular ligand for CD172a. Studies show that CD172a is involved in dendritic cell-mediated T cell activation, neutrophil migration, and phagocytosis.