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CD166 (ALCAM) Mouse anti-Human, PE, Clone: 3A6, eBioscience™

Mouse Monoclonal Antibody

$158.05 - $390.05

Specifications

Antigen CD166 (ALCAM)
Clone 3A6
Host Species Mouse
Gene Alias Activated leukocyte cell adhesion molecule
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501122280

 
affymetrix
12166841
25 tests Each for $158.05

501122281

 
affymetrix
12166842
100 tests Each for $390.05
Description & Specifications

Specifications

Antigen CD166 (ALCAM)
Clone 3A6
Host Species Mouse
Gene Alias Activated leukocyte cell adhesion molecule
Species Reactivity Human
Applications Flow Cytometry
Regulatory Status RUO
Conjugate PE
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.06μg)/test

This 3A6 monoclonal antibody reacts with human CD166, which is also known as activated leukocyte cell adhesion molecule (ALCAM). CD166 is an immunoglobulin superfamily cell adhesion molecule that is broadly expressed on developing and adult hematopoietic (e.g., activated T and B cells, monocytes, and dendritic cells) and non-hematopoietic (e.g., neural, endothelial, and epithelial) tissues. CD166 has also been detected in melanoma, colorectal carcinoma, as well as cancers of the breast, prostate, and bladder. CD166 mediates cell-cell adhesion by forming low-affinity homophilic interactions (ALCAM-ALCAM) or high-affinity heterophilic interactions with its ligand CD6 (ALCAM-CD6). CD166 plays a role in development, inflammation, and neutrophil migration. Moreover, its expression can be used as a prognostic marker for several cancers and has been reported to be a cancer stem cell marker.

The 3A6 antibody has been reported to induce the internalization of CD166 and its recycling back to the cell surface.