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CD163 Mouse anti-Human, APC, Clone: GHI/61, eBioscience™

Mouse Monoclonal Antibody

$160.95 - $397.30

Specifications

Antigen CD163
Clone eBioGHI/61 (GHI/61)
Host Species Mouse
Gene Alias M130, Hemoglobin Scavenger Receptor, Macrophage marker
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501123087

 
affymetrix
17163942
100 tests Each for $397.30

501129151

 
affymetrix
17-1639-41
25 tests Each for $160.95
Description & Specifications

Specifications

Antigen CD163
Clone eBioGHI/61 (GHI/61)
Host Species Mouse
Gene Alias M130, Hemoglobin Scavenger Receptor, Macrophage marker
Species Reactivity Human
Applications Flow Cytometry
Regulatory Status RUO
Conjugate APC
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.5μg)/test

The eBioGHI/61 monoclonal antibody reacts with human CD163 (Haemoglobin Scavenger Receptor, M130), a member of the macrophage scavenger receptor family. CD163 is expressed by tissue macrophages, circulating blood monocytes, and some reports suggest that it may also be expressed by haematopoietic progenitor cells. CD163 functions as a high affinity scavenger receptor for the complex of haemoglobin and haptoglobin which forms to clear haemoglobin from the blood. The high affinity for CD163 is specific for the haemoglobin-haptoglobin complex, whereas haemoglobin or haptoglobin display no to low affinity toward CD163. Upon ligand binding, CD163 initiates signal transduction which leads to the production of IL-6 and IL-10. Furthermore, it has been demonstrated that cytokines such as IL-6 and IL-10 can induce expression of CD163, whereas proinflammatory stimuli, such as LPS or TNF alpha, can cause shedding of a soluble form of CD163, whose function is unclear.