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CD160 Rat anti-Mouse, Clone: eBioCNX46-3 (CNX46-3), eBioscience™

Rat Monoclonal Antibody

$114.55 - $375.55

Specifications

Antigen CD160
Clone eBioCNX46-3 (CNX46-3)
Host Species Rat
Gene Alias BY55
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5012932

 
affymetrix
14-1601-85
500μg Each for $375.55

5012930

 
affymetrix
14-1601-81
50μg Each for $114.55
Description & Specifications

Specifications

Antigen CD160
Clone eBioCNX46-3 (CNX46-3)
Host Species Rat
Gene Alias BY55
Species Reactivity Mouse
Applications Flow Cytometry
Applications Functional Assay
Applications Immunoprecipitation
Applications Western Blotting
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

CD160 is a glycosylphosphatidylinositol (GPI)-anchored Ig-like glycoprotein first identified on human lymphocytes with the monoclonal antibody BY55. In mice, CD160 is expressed on almost all (intestinal intraepithelial lymphocytes) iIELs, NKT cells, most TCRγδ T cells, few NK cells and a minor subset of CD8+ T cells. Murine CD160 has been shown to bind to a wide range of classical and non classical MHC class I molecules and regulate NK cell activation. In vitro, CD3 activation of murine CD8+ T cells increases the expression of CD160 and induces the release of soluble CD160 (sCD160). In human, CD160 mAb cross-linking triggers TNF alpha, IFN gamma and IL-6 cytokine production by peripheral blood NK cells and inhibits tube formation and induces apoptosis of endothelial cells. In mice, cross-linking of CD160 with the CNX46-3 antibody regulates NK cell activation both positively and negatively, depending on the stimulus.