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CD16 Mouse, PE-eFluor 610, Clone: eBioCB16, eBioscience™

Mouse Monoclonal Antibody

$130.68 - $328.68

Specifications

Antigen CD16
Clone eBioCB16 (CB16)
Host Species Murine
Gene Alias Low Affinity IgG Receptor 3, FCGR3a, FCGR3, IGFR5
Species Reactivity Human
View More Specs

Disclaimers:

For Research Use Only.



Products ${productFamilyLength}
Catalog Number Mfr. No. Quantity Price Quantity  
Catalog Number Mfr. No. Quantity Price Quantity  
501124737 Life Technologies
LS61016841
25 Tests Each for $130.68
501124738 Life Technologies
LS61016842
100 Tests Each for $328.68
Specifications

Description

The eBioCB16 monoclonal antibody recognizes CD16 (Fc gamma RIII), the low-affinity receptor for IgG with an apparent molecular weight of 50-80kDa. CD16 is represented by two similar genes, CD16A (Fc gamma RIIIA), which exists as a hetero-oligomeric polypeptide-anchored form in macrophages and NK cells and CD16B (Fc gamma RIIIB), which exists as a monomeric GPI-anchored form in neutrophils. Furthermore, there are two known polymorphisms of CD16B, NA-1 and NA-2. Individuals homozygous for NA-2 show a lower phagocytic capacity compared with NA-1. CD16 binds IgG in the form of immune complexes and shows preferential binding of IgG1 and IgG3 isotypes and minimal binding of IgG2 and IgG4. Upon IgG binding, both CD16 isoforms initiate signal transduction cascades that lead to a variety of responses including antibody-dependent cell-mediated cytotoxicity (ADCC), phagocytosis, degranulation, and proliferation.
Description & Specifications

Specifications

CD16
Murine
Human
RUO
Conjugated
Primary
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
eBioCB16 (CB16)
Low Affinity IgG Receptor 3, FCGR3a, FCGR3, IGFR5
Flow Cytometry
PE-eFluor 610
Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Monoclonal
5μL (0.125μg)/test