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CD16 Mouse anti-Human, Biotin, Clone: eBioCB16 (CB16), eBioscience™

Mouse Monoclonal Antibody

$129.05 - $245.05

Specifications

Antigen CD16
Clone eBioCB16 (CB16)
Host Species Mouse
Gene Alias Low Affinity IgG Receptor 3, FCGR3a, FCGR3, IGFR6
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5011451

 
affymetrix
13-0168-80
25μg Each for $129.05

5011452

 
affymetrix
13016882
100μg Each for $245.05
Description & Specifications

Specifications

Antigen CD16
Clone eBioCB16 (CB16)
Host Species Mouse
Gene Alias Low Affinity IgG Receptor 3, FCGR3a, FCGR3, IGFR6
Species Reactivity Human
Applications Flow Cytometry
Regulatory Status RUO
Conjugate Biotin
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The eBioCB16 monoclonal antibody recognizes CD16 (Fc gammaRIII), the low-affinity receptor for IgG with an apparent molecular weight of 50-80 kDa. CD16 is represented by two similar genes, CD16A (Fc gammaRIIIA), which exists as a hetero-oligomeric polypeptide-anchored form in macrophages and NK cells and CD16B (Fc gammaRIIIB), which exist as a monomeric GPI-anchored form in neutrophils. Furthermore, there are two known polymorphisms of CD16B, NA-1 and NA-2. Individuals homozygous for NA-2 show a lower phagocytic capacity compared with NA-1. CD16 binds IgG in the form of immune complexes and shows preferential binding of IgG1 and IgG3 isotypes and minimal binding of IgG2 and IgG4. Upon IgG binding, both CD16 isoforms initiate signal transduction cascades that lead to a variety of responses including antibody-dependent cell-mediated cytotoxicity (ADCC), phagocytosis, degranulation and proliferation.