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CD152 (CTLA-4) Mouse anti-Human, PE, Clone: 20A, A3, eBioscience™

Mouse Monoclonal Antibody

$143.55 - $375.55

Specifications

Antigen CD152 (CTLA-4)
Clone A3)
Host Species Mouse
Gene Alias CTLA4
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5010654

 
affymetrix
12152841
25 tests Each for $143.55

5010655

 
affymetrix
12152842
100 tests Each for $375.55
Description & Specifications

Specifications

Antigen CD152 (CTLA-4)
Clone A3)
Host Species Mouse
Gene Alias CTLA4
Species Reactivity Human
Applications Flow Cytometry
Regulatory Status RUO
Conjugate PE
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.125μg)/test

The eBio20A monoclonal antibody reacts with human CD152, also known as cytotoxic T lymphocyte antigen-4 (CTLA-4). CTLA-4, a protein with structural similarities to CD28, is expressed on activated T cells (activated B cells may also express CTLA-4) and binds the B7 family members, CD80 (B7-1) and CD86 (B7-2), with higher affinity than CD28 does. CTLA-4 and CD28 appear to deliver opposing signals to T cells: while CD28 is a potent costimulator, CTLA-4 restricts the progression of T cells to an activated state by inhibiting IL-2 secretion and cellular proliferation. The cytoplasmic portion of CTLA-4 contains ER retention motifs, resulting in intracellular localization of a large proportion of newly synthesized CTLA-4 in response to TCR signaling.