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CD152 (CTLA-4) Mouse anti-Human, Clone: 14D3, eBioscience™

Mouse Monoclonal Antibody

$114.55 - $230.55

Specifications

Antigen CD152 (CTLA-4)
Clone 14D3
Host Species Mouse
Species Reactivity Human, Rhesus Ma
Applications Flow Cytometry
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5012919

 
affymetrix
14152982
100μg Each for $230.55

5012918

 
affymetrix
14152980
25μg Each for $114.55
Description & Specifications

Specifications

Antigen CD152 (CTLA-4)
Clone 14D3
Host Species Mouse
Species Reactivity Human, Rhesus Ma
Applications Flow Cytometry
Applications Functional Assay
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The 14D3 monoclonal antibody reacts with human CD152, also known as cytotoxic T lymphocyte antigen-4 (CTLA-4). CTLA-4, a protein with structural similarities to CD28, is expressed on activated T cells (activated B cells may also express CTLA-4) and binds the B7 family members, CD80 (B7-1) and CD86 (B7-2), with higher affinity than CD28 does. CTLA-4 and CD28 appear to deliver opposing signals to T cells: while CD28 is a potent costimulator, CTLA-4 restricts the progression of T cells to an activated state by inhibiting IL-2 secretion and cellular proliferation. The cytoplasmic portion of CTLA-4 contains ER retention motifs, resulting in intracellular localization of a large proportion of newly synthesized CTLA-4 in response to TCR signaling.

The 14D3 antibody also recognizes rhesus monkey and has inhibitor activity.