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CD152 (CTLA-4) Golden Syrian Hamster anti-Mouse, Clone: 9H10, Functional Grade, eBioscience™

Golden Syrian Hamster Monoclonal Antibody, Functional Grade

$129.05 - $404.55

Specifications

Antigen CD152 (CTLA-4)
Clone 9H10
Host Species Golden Syrian Hamster
Gene Alias CTLA4
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5014475

 
affymetrix
16-1521-81
50μg Each for $129.05

5014476

 
affymetrix
16-1521-82
100μg Each for $230.55

5014477

 
affymetrix
16152185
500μg Each for $404.55
Description & Specifications

Specifications

Antigen CD152 (CTLA-4)
Clone 9H10
Host Species Golden Syrian Hamster
Gene Alias CTLA4
Species Reactivity Mouse
Applications Flow Cytometry
Applications Functional Assay
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, no sodium azide
Concentration 1mg/mL

The 9H10 monoclonal antibody reacts with mouse CD152, also known as the cytotoxic T lymphocyte antigen-4 (CTLA-4). CTLA-4, a protein with structural similarities to CD28, is expressed on activated T cells and binds the B7 family members, CD80 (B7-1) and CD86 (B7-2), with higher affinity than CD28 does. CTLA-4 and CD28 appear to deliver opposing signals to T cells: while CD28 is a potent costimulator, CTLA-4 restricts the progression of T cells to an activated state by inhibiting IL-2 secretion and cellular proliferation. The cytoplasmic portion of CTLA-4 contains ER retention motifs, resulting in a large proportion of newly synthesized CTLA-4 in response to TCR signaling to be localized intracellularly.