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CD152 (CTLA-4) Armenian Hamster anti-Mouse, Clone: UC10-4B9, eBioscience™

Armenian Hamster Monoclonal Antibody

$114.55 - $187.05

Specifications

Antigen CD152 (CTLA-4)
Clone UC10-4B9
Host Species Armenian Hamster
Species Reactivity Mouse
Applications Flow Cytometry
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5012915

 
affymetrix
14-1522-81
50μg Each for $114.55

5012916

 
affymetrix
14-1522-82
100μg Each for $187.05
Description & Specifications

Specifications

Antigen CD152 (CTLA-4)
Clone UC10-4B9
Host Species Armenian Hamster
Species Reactivity Mouse
Applications Flow Cytometry
Applications Immunoprecipitation
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The UC10-4B9 monoclonal antibody reacts with mouse CD152, also known as the cytotoxic T lymphocyte antigen-4 (CTLA-4). CTLA-4, a protein with structural similarities to CD28, is expressed on activated T cells at low level and binds the B7 family members, CD80 (B7-1) and CD86 (B7-2), with higher affinity than CD28 does. CTLA-4 and CD28 appear to deliver opposing signals to T cells: while CD28 is a potent costimulator, CTLA-4 restricts the progression of T cells to an activated state by inhibiting IL-2 secretion and cellular proliferation. The cytoplasmic portion of CTLA-4 contains ER retention motifs, resulting in a large proportion of newly synthesized CTLA-4 in response to TCR signaling to be localized intracellularly.
Furthermore, due to the intracellular localization of a large portion of CTLA-4, for complete detection it may be necessary to assess intracellular expression, in addition to surface expression of CTLA-4.