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CD152 (CTLA-4) Armenian Hamster anti-Mouse, APC, Clone: UC10-4B9, eBioscience™

Armenian Hamster Monoclonal Antibody

$158.05 - $419.05

Specifications

Antigen CD152 (CTLA-4)
Clone UC10-4B9
Host Species Armenian Hamster
Species Reactivity Mouse
Applications Flow Cytometry
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5015093

 
affymetrix
17152280
25μg Each for $158.05

5015094

 
affymetrix
17152282
100μg Each for $419.05
Description & Specifications

Specifications

Antigen CD152 (CTLA-4)
Clone UC10-4B9
Host Species Armenian Hamster
Species Reactivity Mouse
Applications Flow Cytometry
Applications Flow Cytometry (Intracellular Staining)
Regulatory Status RUO
Conjugate APC
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

The UC10-4B9 monoclonal antibody reacts with mouse CD152, also known as the cytotoxic T lymphocyte antigen-4 (CTLA-4). CTLA-4, a protein with structural similarities to CD28, is expressed on activated T cells at low level and binds the B7 family members, CD80 (B7-1) and CD86 (B7-2), with higher affinity than CD28 does. CTLA-4 and CD28 appear to deliver opposing signals to T cells: while CD28 is a potent costimulator, CTLA-4 restricts the progression of T cells to an activated state by inhibiting IL-2 secretion and cellular proliferation. The cytoplasmic portion of CTLA-4 contains ER retention motifs, resulting in a large proportion of newly synthesized CTLA-4 in response to TCR signaling to be localized intracellularly.

Furthermore, due to the intracellular localization of a large portion of CTLA-4, for complete detection it may be necessary to assess intracellular expression, in addition to surface expression of CTLA-4.