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CD151 Mouse anti-Human, APC, Clone: 50-6, eBioscience™

Mouse Monoclonal Antibody

$201.55 - $419.05

Specifications

Antigen CD151
Clone 50-6
Host Species Mouse
Gene Alias PETA-3, PETA3
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5015091

 
affymetrix
17-1519-41
25 tests Each for $201.55

5015092

 
affymetrix
17-1519-42
100 tests Each for $419.05
Description & Specifications

Specifications

Antigen CD151
Clone 50-6
Host Species Mouse
Gene Alias PETA-3, PETA3
Species Reactivity Human
Applications Flow Cytometry
Regulatory Status RUO
Conjugate APC
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.125μg)/test

The monoclonal antibody 50-6 recognizes human CD151 also known as PETA-3 (platelet-endothelial cell tetraspan antigen-3). CD151 has a molecular weight of 29kDa and like other tetraspanin family members, CD151 contains four hydrophobic transmembrane domains, two short cytoplasmic tails, and one small and one large extracellular loop. CD151 is expressed on platelets, megakaryocytes, endothelial cells, at the cell-cell junctions, as well as epithelial cells where it localizes to basolateral surfaces exposed to extracellular matrix. The tetraspanins play a role in cell adhesion and migration; CD151 interacts with integrinα3 β1 and integrinα6 β4. In particular CD151 forms a functional complex with c-Met and integrin α3 and α6 in human salivary gland cancer cells. Additionally it can interact with CD46. Together these interactions are thought to play a role during early metastasis as a potential positive effector.
The 50-6 monoclonal antibody inhibits in vivo metastasis of a human epidermal carcinoma cell line, HEp-3.