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CD146 Mouse, eFluor 450, Clone: P1H12, eBioscience™

Mouse Monoclonal Antibody

$160.95 - $397.30

Specifications

Antigen CD146
Clone P1H12
Host Species Mouse
Gene Alias Melanoma Cell Adhesion Molecule, MUC18, Mel-CAM, EndoCAM
Species Reactivity Canine, Human, Mouse, Rabbit
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 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501124142

 
affymetrix
48146941
25 tests Each for $160.95

501124143

 
affymetrix
48146942
100 tests Each for $397.30
Description & Specifications

Specifications

Antigen CD146
Clone P1H12
Host Species Mouse
Gene Alias Melanoma Cell Adhesion Molecule, MUC18, Mel-CAM, EndoCAM
Species Reactivity Canine, Human, Mouse, Rabbit
Applications Flow Cytometry
Regulatory Status RUO
Conjugate eFluor 450
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.125μg)/test

The monoclonal antibody P1H12 recognizes CD146 also known as MUC18, s-endo, Endo-CAM and Mel-CAM, which is a member of the Ig superfamily of proteins. The expression of CD146 is found on endothelial cells, bone marrow fibroblasts and some tumors (especially melanoma). Recently mesenchymal stromal cells and endometrial stromal cells have also been shown to express CD146. The presence of CD146 on circulating blood cells have been confined to a subset of T cells rather than circulating endothelial cells, as expression of other endothelial markers (CD31 and CD51/61) is negative. Expression can be found on activated lymphocytes. The protein is heavily glycosylated with more than 50% of the mass from carbohydrates.

The antibody P1H12 has been reported to crossreact to mouse, rabbit, canine, but not rat.