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CD144 (VE-Cadherin) Rat anti-Mouse, Clone: eBioBV14 (BV14), eBioscience™

Rat Monoclonal Antibody

$216.05 - $361.05

Specifications

Antigen CD144 (VE-Cadherin)
Clone eBioBV14 (BV14)
Host Species Rat
Gene Alias Cadherin 5
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5012893

 
affymetrix
14-1442-82
100μg Each for $216.05

5012894

 
affymetrix
14-1442-85
500μg Each for $361.05
Description & Specifications

Specifications

Antigen CD144 (VE-Cadherin)
Clone eBioBV14 (BV14)
Host Species Rat
Gene Alias Cadherin 5
Species Reactivity Mouse
Applications Functional Assay
Applications Immunohistochemistry (Frozen)
Applications Immunoprecipitation
Applications Western Blotting
Regulatory Status RUO
Conjugate Unlabeled
Format Purified
Storage Requirements Store at 2-8°C.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.5mg/mL

The BV14 monoclonal antibody reacts with mouse VE-Cadherin (CD144). VE-Cadherin is a 120kDa member of the type II Cadherin family, characterized by the presence of 5 extracellular cadherin domains (ECD), and anchored to the actin cytoskeleton through their cytoplasmic tail. VE-Cadherin mediates homophilic adhesion between neighbouring endothelial cells and is localized within specialized structures at cell-cell contacts, called adherens junctions. VE-Cadherin is expressed constitutively throughout the entire vasculature, and is required for numerous endothelial cell functions including migration, survival, contact-dependent growth inhibition and endothelial cell assembly into tubular structures. Furthermore, it is thought that VE-Cadherin+CD45- cells from the yolk sac or aorta-gonad-mesonephros (AGM)+ have the potential to give rise to hematopoietic cells. Cross-blocking experiments suggest that BV14 recognizes a different epitope than another mouse VE-Cadherin monoclonal antibody, BV13.