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CD141 Rat, PE-Cy7, Clone: LS17-9, eBioscience™

Rat Monoclonal Antibody

$216.05 - $448.05

Specifications

Antigen CD141
Clone LS17-9
Host Species Rat
Gene Alias Thrombomodulin, BDCA-3
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501123335

 
affymetrix
25141180
25μg Each for $216.05

501123336

 
affymetrix
25141182
100μg Each for $448.05
Description & Specifications

Specifications

Antigen CD141
Clone LS17-9
Host Species Rat
Gene Alias Thrombomodulin, BDCA-3
Species Reactivity Mouse
Applications Flow Cytometry
Regulatory Status RUO
Conjugate PE-Cy7
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

The monoclonal antibody LS17-9 recognizes mouse CD141 (Thrombomodulin, BDCA-3), a type I cell surface glycoprotein that binds to and allosterically activates thrombin. This complex cleaves protein C and the Thrombin Activatable Fibrinolysis Inhibitor (TAFI), initiating an important anticoagulant and antifibrinolytic pathway. Although expressed across many tissues and cell types, its highest expression has been reported on the lumenal surface of vascular endothelial cell. In the immune system the highest expression can be observed on monocytes and macrophages. Soluble CD141 is constitutively present in the serum at a very low level, and can be upregulated during inflammation. The anti-inflammatory activity of CD141 results from its ability to block the highly pro-inflammatory activity of thrombin. CD141 prevents chemotaxis and binding of granulocytes to activated endothelium, and inhibits activation of eosinophils and mast cells thereby reducing inflammation. Although human CD141 is commonly used as a marker of cross-presenting dendritic cells, mouse CD141 does not exhibit the same expression pattern.