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Thermo Scientific™ Lab Vision™ CD137 (4-1BB) Ab-1, Mouse Monoclonal Antibody


Ensure accurate, reproducible results in immunofluorescence and flow cytometry applications with Thermo Scientific™ CD137 (4-1BB) Ab-1, Mouse Monoclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  MS621P1ABX

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Catalog No. MS621P1ABX

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Description & Specifications

Specifications

Antigen CD137 (4-1BB) Ab-1
Applications Flow Cytometry
Applications Immunofluorescence
Classification Monoclonal
Clone BBK-2
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Format Concentrated
Host Species Murine
Immunogen Ectodomain of human 4-1BB recombinant protein
Isotype IgG1 kappa
Quantity 100μL
Regulatory Status RUO
Research Discipline Apoptosis
Type Primary
Monoclonal or Polyclonal Monoclonal
Target Species Human

Ensure accurate, reproducible results in immunofluorescence and flow cytometry applications with Thermo Scientific™ CD137 (4-1BB) Ab-1, Mouse Monoclonal Antibody.

4-1BB (also known as CD137) is an inducible receptor-like protein expressed on the cell surface of activated splenic T cells and thymocytes. It exists as both a monomer and a dimer on the surface of activated T cells. 4-1BB is structurally related to the members of NGFR/TNFR superfamily which are characterized by the presence of three-six patterns of a cysteine-rich motif in their extracellular domains. Other members of this family include low affinity NGFR, two receptors for TNF (TNFR-I & TNFR-II), CD30, CD40, OX40, Fas, and CD27. These molecules are involved in cell growth, survival, and death processes. The cytoplasmic domain of 4-1BB include two runs of acidic amino acids, a potential p56lck binding site, five consecutive glycines at the C-terminus, and four potential phosphorylation sites: one tyrosine, two threonine, and one serine.

Host Species: Mouse

Clone: BBK-2

Isotype: IgG1/κ

Species Reactivity: Human. Others not known.

Epitope: Ectodomain

Immunogen: Ectodomain of human 4-1BB recombinant protein

Molecular Weight: 30kDa

Positive Control: Spleen, thymus or tonsil

Cellular Localization: Membrane

Recommended for:

  • Immunofluorescence
  • Flow Cytometry

Note:

USA: RUO; Int'l: RUO