Please login to your online account to display your discounted pricing

Thermo Scientific™ Lab Vision™ CD137 (4-1BB) Ab-1, Mouse Monoclonal Antibody


Ensure accurate, reproducible results in immunofluorescence and flow cytometry applications with Thermo Scientific™ CD137 (4-1BB) Ab-1, Mouse Monoclonal Antibody.

Manufacturer: thermo scientific™ lab vision™  MS621P1ABX

 View more versions of this product

Catalog No. MS621P1ABX

  • / Each
 

Description & Specifications

Specifications

Antigen CD137 (4-1BB) Ab-1
Applications Flow Cytometry
Applications Immunofluorescence
Classification Monoclonal
Clone BBK-2
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Format Concentrated
Host Species Mouse
Immunogen Ectodomain of human 4-1BB recombinant protein
Isotype IgG1 kappa
Quantity 100µL
Regulatory Status RUO
Research Discipline Apoptosis
Type Primary

Ensure accurate, reproducible results in immunofluorescence and flow cytometry applications with Thermo Scientific™ CD137 (4-1BB) Ab-1, Mouse Monoclonal Antibody.

4-1BB (also known as CD137) is an inducible receptor-like protein expressed on the cell surface of activated splenic T cells and thymocytes. It exists as both a monomer and a dimer on the surface of activated T cells. 4-1BB is structurally related to the members of NGFR/TNFR superfamily which are characterized by the presence of three-six patterns of a cysteine-rich motif in their extracellular domains. Other members of this family include low affinity NGFR, two receptors for TNF (TNFR-I & TNFR-II), CD30, CD40, OX40, Fas, and CD27. These molecules are involved in cell growth, survival, and death processes. The cytoplasmic domain of 4-1BB include two runs of acidic amino acids, a potential p56lck binding site, five consecutive glycines at the C-terminus, and four potential phosphorylation sites: one tyrosine, two threonine, and one serine.

Host Species: Mouse

Clone: BBK-2

Isotype: IgG1/κ

Species Reactivity: Human. Others not known.

Epitope: Ectodomain

Immunogen: Ectodomain of human 4-1BB recombinant protein

Molecular Weight: 30kDa

Positive Control: Spleen, thymus or tonsil

Cellular Localization: Membrane

Recommended for:

  • Immunofluorescence
  • Flow Cytometry

Note:

USA: RUO; Int'l: RUO