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CD133 Mouse, APC, Clone: EMK08, eBioscience™

Mouse Monoclonal Antibody

$188.50 - $427.75

Specifications

Antigen CD133
Clone EMK08
Host Species Mouse
Gene Alias AC133, Prominin1
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501123078

 
affymetrix
17133941
25 tests Each for $188.50

501123079

 
affymetrix
17133942
100 tests Each for $427.75
Description & Specifications

Specifications

Antigen CD133
Clone EMK08
Host Species Mouse
Gene Alias AC133, Prominin1
Species Reactivity Human
Applications Flow Cytometry
Regulatory Status RUO
Conjugate APC
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, contains stabilizer if necessary
Concentration 5μL (0.125μg)/test

The EMK08 monoclonal antibody reacts with human CD133 (Prominin-1), a 120kDa member of the pentaspan family of proteins, which also includes Prominin-2. Their expression is found within plasma membrane protrusions such as epithelial microvilli. CD133 can exist in a number of alternatively spliced isoforms, and the protein has several N-linked glycosylation sites; the occurrence of both may be tissue-dependent. Human CD133 was first identified as an epitope expressed on CD34+ hematopoietic progenitors. Although the ligand and function of CD133 remain unknown, it has since proven to be very useful as a marker for both stem cells and cancer stem cells. In addition to its expression on hematopoietic precursors, CD133 has been used to identify tumorigenic colon cancer stem cells, brain cancer stem cells, prostate cancer stem cells, in addition to others.

The binding of the EMK08 antibody does not block the binding of another anti-human CD133 antibody, TMP4 (cat. 12-1338) indicating that they recognize distinct epitopes.