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CD126 Rat anti-Mouse, PE-Cy7, Clone: D7715A7, eBioscience™

Rat Monoclonal Antibody

$201.55 - $506.05

Specifications

Antigen CD126
Clone D7715A7
Host Species Rat
Gene Alias Interleukin-6 Receptor alpha
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

501123326

 
affymetrix
25126180
25μg Each for $201.55

501123327

 
affymetrix
25126182
100μg Each for $506.05
Description & Specifications

Specifications

Antigen CD126
Clone D7715A7
Host Species Rat
Gene Alias Interleukin-6 Receptor alpha
Species Reactivity Mouse
Applications Flow Cytometry
Regulatory Status RUO
Conjugate PE-Cy7
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

The monoclonal antibody D7715A7 recognizes mouse CD126, the IL-6 receptor α chain, a member of the Ig superfamily. CD126 can heterodimerize with CD130 (gp130) to form the high affinity IL-6 receptor. Once IL-6 is bound, signaling from the CD130 subunit is initiated and the receptor complex is internalized. The IL-6 receptor is also reported to exist as a soluble version, which bound to IL-6 acts in trans to signal. Expression is found on T lymphocytes in the periphery and during development in the thymus is restricted to SP populations, unlike gp130 which is expressed in all thymocytes. Additional expression has been shown on activated B lymphocytes, macrophages, granulocytes and CD34+ hematopoietic progenitor cells. The monoclonal antibody D7715A7 binding can be blocked addition of ligand (IL-6).