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CD126 Mouse anti-Human, PerCP-eFluor 710, Clone: 47.7G7.1F2, eBioscience™

Mouse Monoclonal Antibody

$172.55 - $419.05

Specifications

Antigen CD126
Clone 47.7G7.1F2
Host Species Mouse
Gene Alias Interleukin-6 Receptor alpha, IL-6Ra
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5016009

 
affymetrix
46-1269-41
25 tests Each for $172.55

5016010

 
affymetrix
46-1269-42
100 tests Each for $419.05
Description & Specifications

Specifications

Antigen CD126
Clone 47.7G7.1F2
Host Species Mouse
Gene Alias Interleukin-6 Receptor alpha, IL-6Ra
Species Reactivity Human
Applications Flow Cytometry
Regulatory Status RUO
Conjugate PerCP-eFluor 710
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.06μg)/test

This monoclonal antibody 47.7G7.1F2 reacts with human CD126, also known as IL-6 receptor alpha. It associates with the gp130 chain to form the high-affinity receptor for IL-6. Although gp130 is ubiquitously expressed, CD126 is only found on mature T cells, activated B cells, macrophages, hepatocytes, and myeloma cells. Upon binding to IL-6, two heterotrimeric complexes of receptor and ligand associate into a hexamer and are then internalized, initializing Jak/STAT signaling pathways. IL-6 induces the proliferation and survival of T cells, Th2 differentiation, and acute-phase protein production in the liver. A soluble form of CD126 lacking the transmembrane domain is also present and can be generated by cleavage at the cell surface or alternative splicing. Soluble CD126 can bind IL-6 and activate cells expressing only gp130 through trans-presentation.