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CD11b (activation epitope) Mouse anti-Human, APC, Clone: CBRM1/5, eBioscience™

Mouse Monoclonal Antibody

$201.55 - $448.05

Specifications

Antigen CD11c
Clone N418
Host Species Armenian Hamster
Gene Alias Integrin alpha X, Integrin aX, ITGAX, p150/95, leu M5 alpha
Species Reactivity Mouse
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5014888

 
affymetrix
17-0113-41
25 tests Each for $201.55

5014889

 
affymetrix
17011342
100 tests Each for $448.05

501129523

 
affymetrix
17-0114-81
50μg Each for $245.05

501129650

 
affymetrix
17-0114-82
100μg Each for $404.55
Description & Specifications

Specifications

Antigen CD11c
Clone N418
Host Species Armenian Hamster
Gene Alias Integrin alpha X, Integrin aX, ITGAX, p150/95, leu M5 alpha
Species Reactivity Mouse
Applications Flow Cytometry
Regulatory Status RUO
Conjugate APC
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 0.2mg/mL

The CBRM1/5 monoclonal antibody reacts with an activation-specific epitope of human Mac-1. CBRM1/5 binds a subset of Mac-1 molecules on neutrophils and monocytes after stimulation with chemoattractants or phorbol esters but does not recognize Mac-1 on resting myeloid cells. Through interactions with its ligands, Mac-1 participates in adhesive cell interactions. The epitope recognized by this mAb localizes to the I domain on the α chain of Mac-1 very close to the ligand binding site in a region that is widely exposed. CBRM1/5 blocks Mac-1 dependent adhesion to fibrinogen and ICAM-1 and inhibits chemoattractant-stimulated adhesion of eosinophils to the Intercellular Adhesion Molecule-1 (ICAM-1). It should be noted that low level activation may occur during processing of freshly drawn blood. Therefore the CBRM1.5 antibody may exhibit some binding to Mac-1 in these unstimulated samples. However, higher levels of Mac-1 expression are observed in activated samples when compared to unstimulated cells.