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CD115 (c-fms) Rat anti-Mouse, Alexa Fluor® 488, Clone: AFS98, eBioscience™

Rat Monoclonal Antibody

Manufacturer:  Life Technologies LS53115280

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Catalog No. 501129186



Description

Description

Description: The AFS98 monoclonal antibody reacts with the mouse CD115 molecule, a receptor for macrophage colony stimulating factor (M-CSF) or colony stimulating factor-1 (CSF-1). CD115 is expressed by monocyte, macrophage, osteoclast, and some epithelial cells. It is a 150 kDa c-fms gene product and belongs to immunoglobulin family. CSF-1 signaling through CSF-1R regulates the proliferation and differentiation of cells in the monocytic lineage. Applications Reported: This AFS98 antibody has been reported for use in flow cytometric analysis. Applications Tested: This AFS98 antibody has been tested by flow cytometric analysis of mouse peritoneal elicited cells. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10e5 to 10e8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Excitation: 488 nm; Emission: 519 nm; Laser: Blue Laser. Filtration: 0.2 μm post-manufacturing filtered.

The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid maligcy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction.
Specifications

Specifications

CD115 (c-fms)
Monoclonal
0.5 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
P09581
C-FMS, CD115, CSFR, FIM2, FMS
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
Flow Cytometry
AFS98
Alexa Fluor® 488
Csf1r
Liquid
Csf1r
IgG2a, kappa
25 μg
4° C, store in dark, DO NOT FREEZE!
Primary
12978
Documents

For Research Use Only.