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CD115 (c-fms) Rat anti-Human, PE, Clone: 12-3A3-1B10, eBioscience™

Rat Monoclonal Antibody

$187.05 - $448.05

Specifications

Antigen CD115 (c-fms)
Clone 12-3A3-1B10
Host Species Rat
Gene Alias CSF1R, colony-stimulating factor 1 Receptor
Species Reactivity Human
View More Specs

 Disclaimers

For Research Use Only.

Products
Catalog Number Mfr. No. Quantity Price Quantity    

5010565

 
affymetrix
12115941
25 tests Each for $187.05

5010566

 
affymetrix
12115942
100 tests Each for $448.05
Description & Specifications

Specifications

Antigen CD115 (c-fms)
Clone 12-3A3-1B10
Host Species Rat
Gene Alias CSF1R, colony-stimulating factor 1 Receptor
Species Reactivity Human
Applications Flow Cytometry
Regulatory Status RUO
Conjugate PE
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration 5μL (0.03μg)/test

CD115 or Colony-Stimulating Factor-1 Receptor (CSF-1R) is expressed on cells committed to the monocyte lineage and osteoclasts. CSF-1R is a disulfide-linked homodimer, which upon binding of its ligand, CSF-1, undergoes tyrosine autophosphorylation and subsequently, phosphorylates other membrane-proximal downstream targets which results in cytoskeletal remodeling, gene transcription and protein translation. CSF-1R activation promotes the survival, proliferation and differentiation of mononuclear phagocytes and the spreading and motility of macrophages. In osteoclasts, CSF-1R synergizes with RANKL to regulate the differentiation of mononuclear phagocytes to osteoclasts.