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Thermo Scientific™ Lab Vision™ CD115/c-fms/CSF-1R/M-CSFR Ab-1, Rat Monoclonal Antibody


Ensure accurate, reproducible results in immunohistochemistry and immunofluorescence experiments.

Manufacturer: thermo scientific™ lab vision™  RT601P1ABX

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Catalog No. RT601P1ABX

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Description & Specifications

Specifications

Antigen CD115/c-fms/CSF-1R/M-CSFR Ab-1
Applications Immunohistochemistry (Frozen)
Classification Monoclonal
Clone 2-4A5-4
Concentration 1mg/mL
Conjugate Unlabeled
Cross Reactivity Human
Format Concentrated
Host Species Rat
Immunogen v-ras-transformed rat NRK cells expressing transduced human CSF-1R
Isotype IgG2a kappa
Quantity 100µL
Regulatory Status RUO
Type Primary

Ensure accurate, reproducible results in immunohistochemistry and immunofluorescence experiments with Thermo Scientific™ CD115/c-fms/CSF-1R/M-CSFR Ab-1, Rat Monoclonal Antibody.

CD115, also known as c-fms, macrophage Colony Stimulating Factor Receptor (M-CSFR), or CSF-1R, exists in immature (gp130c-fms) and mature (gp150c-fms) forms. CSF-1R exhibits an intrinsic tyrosine-specific protein kinase activity. It is expressed on the cells of the mononuclear phagocyte lineage. CSF-1R is an integral transmembrane glycoprotein consisting of a 512 amino acid extracellular domain that includes the CSF-1 binding site, a single 25 amino acid membrane-spanning segment, and a 435 amino acid cytoplasmic portion that includes the tyrosine kinase domain.

Host Species: Rat

Clone: 2-4A5-4

Isotype: IgG1/κ

Species Reactivity: Human. Does not react with mouse and cat. Others not known.

Epitope: aa 349-512

Immunogen: v-ras-transformed rat NRK cells expressing transduced human CSF-1R

Molecular Weight: 130 and 150 kDa

Positive Control: Tonsil

Cellular Localization: Membrane

Recommended for:

  • Immunohistochemistry (Acetone-fixed frozen)
  • Immunofluorescence
  • Blocks Ligand Binding
  • Blocks Ligand-dependent Proliferation
  • Inhibits CSF-1-independent Growth of Cells Expressing Mutant CSF-1R

Note:

USA: RUO; Int'l: RUO