Thermo Scientific™ Lab Vision™ CD115/c-fms/CSF-1R/M-CSFR Ab-1, Rat Monoclonal Antibody
Ensure accurate, reproducible results in immunohistochemistry and immunofluorescence experiments.
Manufacturer: Thermo Scientific™ Lab Vision™ RT601P1ABX
Ensure accurate, reproducible results in immunohistochemistry and immunofluorescence experiments with Thermo Scientific™ CD115/c-fms/CSF-1R/M-CSFR Ab-1, Rat Monoclonal Antibody.CD115, also known as c-fms, macrophage Colony Stimulating Factor Receptor (M-CSFR), or CSF-1R, exists in immature (gp130c-fms) and mature (gp150c-fms) forms. CSF-1R exhibits an intrinsic tyrosine-specific protein kinase activity. It is expressed on the cells of the mononuclear phagocyte lineage. CSF-1R is an integral transmembrane glycoprotein consisting of a 512 amino acid extracellular domain that includes the CSF-1 binding site, a single 25 amino acid membrane-spanning segment, and a 435 amino acid cytoplasmic portion that includes the tyrosine kinase domain.
Host Species: Rat
Species Reactivity: Human. Does not react with mouse and cat. Others not known.
Epitope: aa 349-512
Immunogen: v-ras-transformed rat NRK cells expressing transduced human CSF-1R
Molecular Weight: 130 and 150 kDa
Positive Control: Tonsil
Cellular Localization: Membrane
- Immunohistochemistry (Acetone-fixed frozen)
- Blocks Ligand Binding
- Blocks Ligand-dependent Proliferation
- Inhibits CSF-1-independent Growth of Cells Expressing Mutant CSF-1R
USA: RUO; Int'l: RUO
|v-ras-transformed rat NRK cells expressing transduced human CSF-1R|